BCL3

Also known as BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, BCL3, transcription coactivator, BCL3 transcription coactivator

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

Gene data

BCL3

Name: BCL3 transcription coactivator
Type: protein-coding
Aliases: BCL4, D19S37

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

BCL3 transcription coactivator

Symbol: BCL3
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:44,747,705-44,760,044
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein BCL3 PDB 1k1a.png

Show 5 more facts

HomoloGene ID: 81738
exact match: identifiers.org/ncbigene/602
genomic end: 45263301
genomic start: 45250962
cytogenetic location: 19q13.32

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Interactions
Clinical significance
Role in cancer therapy
Development
References
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B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.