NFKB2

Name

nuclear factor kappa B subunit 2

Type

protein-coding

Position

102,394,110–102,402,529 (+)

Aliases

CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52

Ensembl

ENSG00000077150

RefSeq RNA

NM_001077494.3, NM_001261403.3, NM_001288724.1, NM_001322934.2, NM_001322935.1

RefSeq protein

NP_001070962.1, NP_001248332.1, NP_001275653.1, NP_001309863.1, NP_001309864.1

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

via MyGene.info

Gene · Ensembl

nuclear factor kappa B subunit 2

Symbol

NFKB2

Biotype

Protein coding

Organism

Homo sapiens

Location

10:102,394,110-102,402,529

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein NFKB2 PDB 1a3q.png

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