Dermcidin
Sign in to saveAlso known as diffusible survival/evasion peptide, proteolysis inducing factor, DCD, survival promoting peptide, preproteolysin
Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene. The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides, secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. PIF is involved in muscular proteolysis.
Protein · UniProt
Dermcidin
- Gene
- DCD
- Organism
- Homo sapiens (Human)
- Length
- 110 aa
- Molecular mass
- 11,284 Da
- Evidence
- 1: Evidence at protein level
Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed:11694882, PubMed:23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes (PubMed:23426625). Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival (PubMed:23426625). Highly effective against E.coli, E.faecalis, S.aureus and C.albicans (PubMed:11694882). Optimal pH and salt concentration resemble the conditions in sweat (PubMed:11694882). Also ex…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- COMPLETEDGestational Diabetes and Human Milk Composition StudyMarmara University · NCT07051681
~2 min read
Article
5 sectionsContents
- Function
- Mechanism
- References
- Further reading
- External links
Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene. The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides, secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. PIF is involved in muscular proteolysis.
== Function ==