diphtheria toxin

Protein · UniProt

Diphtheria toxin

Organism

Corynephage omega

Length

560 aa

Molecular mass

60,815 Da

Evidence

4: Predicted

Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2. Fragment A is responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A

• Diphtheria toxin.Pharmacology & therapeutics · 1982
• Diphtheria toxin: mode of action and structure.Bacteriological reviews · 1975
• Diphtheria.Science (New York, N.Y.) · 1973
• Pentasaccharide anticoagulant fondaparinux inhibits diphtheria toxin.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
• The diphtheria toxin structural gene.Current topics in microbiology and immunology · 1985

via PubMed

Wikidata facts

Instance of

protein

Subclass of

exotoxin

Image

PDB 1xdt EBI.jpg

via Wikidata · CC0