histatin
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Histatins are histidine-rich (cationic) antimicrobial proteins found in saliva. Histatin's involvement in antimicrobial activities makes histatin part of the innate immune system. Histatin was first discovered (isolated) in 1988, with functions that are responsible in keeping homeostasis inside the oral cavity, helping in the formation of pellicles, and assist in bonding of metal ions.
Research
713 papers- Histatin 5 Metallopeptides and Their Potential against Candida albicans Pathogenicity and Drug Resistance.Biomolecules · 2021
- Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair.Free radical biology & medicine · 2024
- Histatin peptides: Pharmacological functions and their applications in dentistry.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017
- Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide.Journal of fungi (Basel, Switzerland) · 2021
- Histatin-Photodynamic Therapy for Polyene-Resistant Biofilms in a 3D Model.Journal of dental research · 2025
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Sources (2)
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Article
6 sectionsContents
- Structure
- Function
- Antifungal activity
- Wound healing
- Cell migration
- References
Histatins are histidine-rich (cationic) antimicrobial proteins found in saliva. Histatin's involvement in antimicrobial activities makes histatin part of the innate immune system. Histatin was first discovered (isolated) in 1988, with functions that are responsible in keeping homeostasis inside the oral cavity, helping in the formation of pellicles, and assist in bonding of metal ions.
__TOC__ == Structure == The structure of histatin is unique depending on whether the protein of interest is histatin 1, 3 or 5. Nonetheless, histatins mainly possess a cationic (positive) charge due to the primary structure consisting mostly of basic amino acids. An amino acid that is crucial to histatin's function is histidine. Studies show that the removal of histidine (especially in histatin 5) resulted in reduction of antifungal activity.