POLD2
Sign in to saveAlso known as DNA polymerase delta 2, accessory subunit
DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.
Gene data
POLD2- Name
- DNA polymerase delta 2, accessory subunit
- Type
- protein-coding
- Position
- 44,114,631–44,124,407 (−)
- Ensembl
- ENSG00000106628
- RefSeq RNA
- NM_001127218.3, NM_001256879.2, NM_006230.4, XM_024446802.2, XM_047420497.1
- RefSeq protein
- NP_001120690.1, NP_001243808.1, NP_006221.3, XP_024302570.1, XP_047276453.1
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DNA polymerase delta 2, accessory subunit
- Symbol
- POLD2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:44,114,631-44,124,407
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4538
- exact match
- identifiers.org/ncbigene/5425
- genomic end
- 44163957
- genomic start
- 44154286
- cytogenetic location
- 7p13
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- References
- Further reading
- External links
DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.
==Interactions== POLD2 has been shown to interact with PCNA.