POLD4

Also known as POLDS, p12, polymerase (DNA) delta 4, accessory subunit, DNA polymerase delta 4, accessory subunit

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.

Gene data

POLD4

Name: DNA polymerase delta 4, accessory subunit
Type: protein-coding
Position: 67,350,772–67,356,972 (−)
Aliases: POLDS, p12
Ensembl: ENSG00000175482
RefSeq RNA: NM_001256870.2, NM_021173.5, NR_046411.2, NR_046412.2, NR_046413.1
RefSeq protein: NP_001243799.1, NP_066996.3

This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].

Gene Ontology

Biological process

DNA synthesis involved in DNA repair

Article

2 sections

Contents

References
Further reading

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.

==References==