BCL2L11

Name

BCL2 like 11

Type

protein-coding

Position

111,119,378–111,168,444 (+)

Aliases

BAM, BIM, BOD

Ensembl

ENSG00000153094

RefSeq RNA

NM_001204106.2, NM_001204107.1, NM_001204108.1, NM_001204109.2, NM_001204110.2

RefSeq protein

NP_001191035.1, NP_001191036.1, NP_001191037.1, NP_001191038.1, NP_001191039.1

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013].

via MyGene.info

Gene · Ensembl

BCL2 like 11

Symbol

BCL2L11

Biotype

Protein coding

Organism

Homo sapiens

Location

2:111,119,378-111,168,444

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein BCL2L11 PDB 2K7W.png

via Wikidata · CC0