MRTFB

Also known as MRTF-B, NPD001, MKL1/myocardin like 2, myocardin related transcription factor B, MKL2

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.

In the Vinony graph

Within Vinony's link graph, MRTFB is referenced by 2 other articles, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 16.

Its subject is documented across 6 Wikipedia language editions.

Gene data

MRTFB

Name: myocardin related transcription factor B
Type: protein-coding
Position: 14,071,058–14,266,778 (+)
Aliases: MKL2, MRTF-B, NPD001
Ensembl: ENSG00000186260
RefSeq RNA: NM_001308142.2, NM_001365411.2, NM_001365412.2, NM_001365413.2, NM_001365414.2
RefSeq protein: NP_001295071.1, NP_001352340.1, NP_001352341.1, NP_001352342.1, NP_001352343.1

Enables transcription coactivator activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II and positive regulation of striated muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

positive regulation of striated muscle tissue development positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II smooth muscle cell differentiation positive regulation of miRNA transcription positive regulation of miRNA transcription

Molecular function

transcription coactivator activity transcription coactivator activity transcription coactivator activity transcription coactivator activity protein binding cadherin binding

Cellular component

nucleus nucleus nucleus nuclear speck

via MyGene.info

Gene · Ensembl

myocardin related transcription factor B

Symbol: MRTFB
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:14,071,058-14,266,778
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 40917
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/57496
genomic end: 14360630
genomic start: 14165178
chromosome: human chromosome 16
cytogenetic location: 16p13.12
expressed in: Brodmann area 46

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.

Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function and addiction.

Excerpted from Wikipedia’s “MRTFB” article, available under the CC BY-SA 4.0 licence.