MRTFB

Also known as MRTF-B, NPD001, MKL1/myocardin like 2, myocardin related transcription factor B, MKL2

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.

Gene data

MRTFB

Name: myocardin related transcription factor B
Type: protein-coding
Position: 14,071,058–14,266,778 (+)
Aliases: MKL2, MRTF-B, NPD001
Ensembl: ENSG00000186260
RefSeq RNA: NM_001308142.2, NM_001365411.2, NM_001365412.2, NM_001365413.2, NM_001365414.2
RefSeq protein: NP_001295071.1, NP_001352340.1, NP_001352341.1, NP_001352342.1, NP_001352343.1

Enables transcription coactivator activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II and positive regulation of striated muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

positive regulation of striated muscle tissue development positive regulation of transcription by RNA polymerase II

Article

2 sections

Contents

References
Further reading

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.

Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function and addiction.