MRAP2
Sign in to saveAlso known as BMIQ18, C6orf117, bA51G5.2, melanocortin 2 receptor accessory protein 2
Melanocortin 2 receptor accessory protein 2 is a protein that in humans is encoded by the MRAP2 gene. MRAP2 is a transmembrane accessory protein to a family of five receptors called the melanocortin receptors (MC1-5). Human genome sequencing analysis led to the discovery of MRAP2, Human MRAP2 gene is located in chromosome 6q14.3, a different chromosomal location from that of human MRAP which is a paralogy to MRAP2. MRAP2 is thought to be involved in regulating the expression of the melanocortin (MC1-5) and some non-melanocortin receptors such as ghrelin receptor (GHSR-1a), orexin (OX1R) recep
Gene data
MRAP2- Name
- melanocortin 2 receptor accessory protein 2
- Type
- protein-coding
- Aliases
- C6orf117, bA51G5.2
This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016].
via MyGene.info
Gene · Ensembl
melanocortin 2 receptor accessory protein 2
- Symbol
- MRAP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:84,033,203-84,090,887
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 16307
- exact match
- identifiers.org/ncbigene/112609
- genomic end
- 84800600
- genomic start
- 84033772
- cytogenetic location
- 6q14.2
Sources (3)
via Wikidata · CC0
~8 min read
Article
6 sectionsContents
- Structure and functional regions
- Cellular activity
- Obesity
- Notes
- References
- Further reading
Melanocortin 2 receptor accessory protein 2 is a protein that in humans is encoded by the MRAP2 gene. MRAP2 is a transmembrane accessory protein to a family of five receptors called the melanocortin receptors (MC1-5). Human genome sequencing analysis led to the discovery of MRAP2, Human MRAP2 gene is located in chromosome 6q14.3, a different chromosomal location from that of human MRAP which is a paralogy to MRAP2. MRAP2 is thought to be involved in regulating the expression of the melanocortin (MC1-5) and some non-melanocortin receptors such as ghrelin receptor (GHSR-1a), orexin (OX1R) receptor and prokineticin receptor (PKR-1).
MRAP2 was found first in the adrenal gland and the brain. However, the Human protein Atlas/ RNA-seq analysis data of human genome detected MRAP2 in other tissues such as ovary, endometrium, testis, digestive tract, pituitary gland and skin.