MTCH2
Sign in to saveAlso known as MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.
In the Vinony graph
Vinony's link graph records 5 inbound references to MTCH2, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Vinony links it to 5 Wikipedia language editions.
Gene data
MTCH2- Name
- mitochondrial carrier 2
- Type
- protein-coding
- Position
- 47,604,339–47,642,698 (−)
- Aliases
- HSPC032, MIMP, SLC25A50
- Ensembl
- ENSG00000285121
- RefSeq RNA
- NM_001317231.2, NM_001317232.2, NM_001317233.2, NM_014342.4, XM_006718172.3
- RefSeq protein
- NP_001304160.1, NP_001304161.1, NP_001304162.1, NP_055157.1, XP_006718235.1
This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
mitochondrial carrier 2
- Symbol
- MTCH2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:47,604,339-47,642,698
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 8645
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23788
- genomic end
- 47642607
- genomic start
- 47638867
- chromosome
- human chromosome 11
- cytogenetic location
- 11p11.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Clinical significance
- See also
- References
- Further reading
Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.
MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID.
Excerpted from Wikipedia’s “MTCH2” article, available under the CC BY-SA 4.0 licence.