MTIF2
Sign in to saveAlso known as mitochondrial translational initiation factor 2
Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.
Gene data
MTIF2- Name
- mitochondrial translational initiation factor 2
- Type
- protein-coding
- Position
- 55,236,230–55,270,263 (−)
- Ensembl
- ENSG00000085760
- RefSeq RNA
- NM_001005369.1, NM_001321001.1, NM_001321002.1, NM_001321003.1, NM_001321004.1
- RefSeq protein
- NP_001005369.1, NP_001307930.1, NP_001307931.1, NP_001307932.1, NP_001307933.1
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
mitochondrial translational initiation factor 2
- Symbol
- MTIF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:55,236,218-55,270,263
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1840
- exact match
- identifiers.org/ncbigene/4528
- genomic end
- 55496483
- genomic start
- 55463731
- cytogenetic location
- 2p16.1
Sources (4)
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Article
2 sectionsContents
- References
- Further reading
Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.