MTA2

Also known as MTA1L1, PID, metastasis associated 1 family member 2

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

Gene data

MTA2

Name: metastasis associated 1 family member 2
Type: protein-coding
Aliases: MTA1L1, PID

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011].

via MyGene.info

Gene · Ensembl

metastasis associated 1 family member 2

Symbol: MTA2
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:62,593,214-62,601,927
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Research

205 papers

MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells.Signal transduction and targeted therapy · 2021
A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin.Nature communications · 2024
MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression.Aging · 2024
MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity.Cell death & disease · 2019
Role of MTA2 in human cancer.Cancer metastasis reviews · 2014

via PubMed

Wikidata facts

Show 5 more facts

HomoloGene ID: 3480
exact match: identifiers.org/ncbigene/9219
genomic end: 62601865
genomic start: 62360686
cytogenetic location: 11q12.3

Sources (3)

via Wikidata · CC0

~4 min read

Article

10 sections

Contents

Discovery
Gene and spliced variants
Structure
Function
Regulation
Targets
Interactions
Notes
References
External links

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

MTA2 is the second member of the MTA family of genes. MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex (NuRD). Similar to the founding family member MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression. MTA2 is overexpressed in human cancer and its dysregulated level correlates well with cancer invasiveness and aggressive phenotypes.