MRGPRX2
Sign in to saveAlso known as MGRG3, MRGX2, MAS related GPR family member X2
Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.
Gene data
MRGPRX2- Name
- MAS related GPR family member X2
- Type
- protein-coding
- Aliases
- MGRG3, MRGX2
Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
MAS related GPR family member X2
- Symbol
- MRGPRX2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:19,054,455-19,060,717
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 24986
- exact match
- identifiers.org/ncbigene/117194
- genomic end
- 19060717
- genomic start
- 19076002
- cytogenetic location
- 11p15.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- See also
- References
- Further reading
Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.
Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome), icatibant, leuprolide, and morphine.