dynamin
Sign in to saveAlso known as Dynamin-type guanine nucleotide-binding (G) domain, protein family, IPR030381, dynamins
Dynamin is a GTPase protein responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. Members of the dynamin family are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface (particularly caveolae internalization) as well as at the Golgi apparatus. Dynamin family members also play a role in many processes including div
Key facts
- Protein family.Symbol
- Dynamin_M
- Protein family.Name
- Dynamin central region
- Protein family.image
- PDB 2aka EBI.jpg
- Protein family.caption
- Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin I from Rattus norvegicus
- Protein family.Pfam
- PF01031
- Protein family.Pfam_clan
- CL0023
- Protein family.InterPro
- IPR000375
- Protein family.PROSITE
- PDOC00362
via Wikipedia infobox
Research
8,695 papers- Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking.Cells · 2022
- Dynamin spirals.Current opinion in structural biology · 1999
- The dynamin superfamily.Current biology : CB · 2018
- "Gearing" up for dynamin-catalyzed membrane fission.Current opinion in cell biology · 2023
- Dynamin and cytokinesis.Traffic (Copenhagen, Denmark) · 2006
via PubMed
Wikidata facts
Show 1 more fact
- Commons category
- Dynamins
Sources (2)
via Wikidata · CC0
~3 min read
Article
7 sectionsContents
- Structure
- Function
- Types
- Pharmacology
- Disease implications
- References
- External links
Dynamin is a GTPase protein responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. Members of the dynamin family are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface (particularly caveolae internalization) as well as at the Golgi apparatus. Dynamin family members also play a role in many processes including division of organelles, cytokinesis and microbial pathogen resistance.
== Structure == thumb|left|Dynamin assembled into helical polymers as visualized by negative stain electron microscopy.|alt=