CFL1
Sign in to saveAlso known as CFL, HEL-S-15, cofilin, cofilin 1
protein-coding gene in the species Homo sapiens
Gene data
CFL1- Name
- cofilin 1
- Type
- protein-coding
- Position
- 65,823,022–65,862,026 (−)
- Aliases
- CFL, HEL-S-15, cofilin
- Ensembl
- ENSG00000172757
- RefSeq RNA
- NM_005507.3
- RefSeq protein
- NP_005498.1
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004].
Gene Ontology
Biological process
Molecular function
Pathways
Axon guidance - Homo sapiens (human)Fc gamma R-mediated phagocytosis - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Pertussis - Homo sapiens (human)Human immunodeficiency virus 1 infection - Homo sapiens (human)HemostasisPlatelet degranulation Developmental BiologyCytokine Signaling in Immune systemSignal Transduction
via MyGene.info
Gene · Ensembl
cofilin 1
- Symbol
- CFL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,823,022-65,862,026
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CFL1 PDB 1q8g.png
Show 8 more facts
- HomoloGene ID
- 99735
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1072
- genomic end
- 65629497
- genomic start
- 65590493
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.1
- expressed in
- pylorus
Sources (4)
via Wikidata · CC0