CFL1
Sign in to saveAlso known as CFL, HEL-S-15, cofilin, cofilin 1
protein-coding gene in the species Homo sapiens
Gene data
CFL1- Name
- cofilin 1
- Type
- protein-coding
- Aliases
- CFL, HEL-S-15, cofilin
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004].
via MyGene.info
Gene · Ensembl
cofilin 1
- Symbol
- CFL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,823,022-65,862,026
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CFL1 PDB 1q8g.png
Show 5 more facts
- HomoloGene ID
- 99735
- exact match
- identifiers.org/ncbigene/1072
- genomic end
- 65629497
- genomic start
- 65590493
- cytogenetic location
- 11q13.1
Sources (4)
via Wikidata · CC0
Connections
hair keratin
Entity
Q180686
Entity
human chromosome 11
Entity
Ensembl genome database project
Entity
cytokeratin
Entity
protein
Entity
Wikidata
Entity
gene
Entity
chromosome
Entity
digital object identifier
Entity
cytoplasm
Entity
cytoskeleton
Entity
bibcode
Entity
keratins
Entity
Science
Entity
human genome
Entity
Q229883
Entity
base pair
Entity
actin
Entity
microtubule
Entity