STAB1
Sign in to saveAlso known as CLEVER-1, FEEL-1, FELE-1, FEX1, STAB-1, SCARH2, stabilin 1, FEEL1
Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.
In the Vinony graph
Within Vinony's link graph, STAB1 is referenced by 10 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 3.
Its subject is documented across 5 Wikipedia language editions.
Gene data
STAB1- Name
- stabilin 1
- Type
- protein-coding
- Position
- 52,495,331–52,524,512 (+)
- Aliases
- CLEVER-1, FEEL-1, FEEL1, FELE-1, FEX1, HRFT, SCARH2, STAB-1
- Ensembl
- ENSG00000010327
- RefSeq RNA
- NM_015136.3, XM_005264973.4, XM_005264974.2, XM_006713065.1, XM_047447774.1
- RefSeq protein
- NP_055951.2, XP_005265030.1, XP_005265031.1, XP_006713128.1, XP_047303730.1
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
stabilin 1
- Symbol
- STAB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:52,495,331-52,524,512
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 9035
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23166
- chromosome
- human chromosome 3
- genomic start
- 52529354
- genomic end
- 52558511
- cytogenetic location
- 3p21.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. STAB1 is also known to interact with the protein chitinase domain-containing protein 1.
Excerpted from Wikipedia’s “STAB1” article, available under the CC BY-SA 4.0 licence.