HUS1
Sign in to saveAlso known as hHUS1, HUS1 checkpoint clamp component
Checkpoint protein HUS1 is a protein that in humans is encoded by the HUS1 gene.
Gene data
HUS1- Name
- HUS1 checkpoint clamp component
- Type
- protein-coding
- Aliases
- hHUS1
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011].
via MyGene.info
Gene · Ensembl
HUS1 checkpoint clamp component
- Symbol
- HUS1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:47,961,882-47,979,682
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein RAD9A PDB 3A1J.png
Show 5 more facts
- HomoloGene ID
- 37932
- exact match
- identifiers.org/ncbigene/3364
- genomic start
- 47963288
- genomic end
- 47979615
- cytogenetic location
- 7p12.3
Sources (3)
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- In somatic cells
- In meiosis
- Interactions
- References
- Further reading
Checkpoint protein HUS1 is a protein that in humans is encoded by the HUS1 gene.
== Function ==