P2RY2

Also known as HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.

Gene data

P2RY2

Name: purinergic receptor P2Y2
Type: protein-coding
Position: 73,216,664–73,242,427 (+)
Aliases: HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R
Ensembl: ENSG00000175591
RefSeq RNA: NM_002564.4, NM_176071.3, NM_176072.3
RefSeq protein: NP_002555.4, NP_788085.3, NP_788086.3

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013].

Gene Ontology

Biological process

intracellular monoatomic ion homeostasis G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled purinergic nucleotide receptor signaling pathway positive regulation of mucus secretion cellular response to ATP

Molecular function

G protein-coupled receptor activity protein binding A1 adenosine receptor binding A1 adenosine receptor binding signaling receptor activity G protein-coupled purinergic nucleotide receptor activity G protein-coupled UTP receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane membrane

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Inflammatory mediator regulation of TRP channels - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)GPCR downstream signalling Metabolism of proteins G alpha (q) signalling events P2Y receptors Nucleotide-like (purinergic) receptors

via MyGene.info

Gene · Ensembl

purinergic receptor P2Y2

Symbol: P2RY2
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:73,216,664-73,242,427
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 1927
exact match: identifiers.org/ncbigene/5029
genomic end: 73242427
genomic start: 73218281
cytogenetic location: 11q13.4

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P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.

The product of this gene, P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.