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diquafosol

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Also known as INS-365, INS365, P1,P4-Bis(5'-uridyl) tetrahydrogen tetraphosphate, UppppU

Diquafosol (tradename Diquas) is a pharmaceutical drug for the treatment of dry eye disease. It was approved for use in Japan in 2010. It is formulated as a 3% ophthalmic solution of the tetrasodium salt.

Wikidata facts

Mass
789.994
Show 4 more facts
World Health Organisation international non-proprietary name
diquafosol
chemical formula
C₁₈H₂₆N₄O₂₃P₄
isomeric SMILES
C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=CC(=O)NC4=O)O)O)O)O
canonical SMILES
C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O
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Encyclopedic overview

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{{Chembox | ImageFile = Diquafosol.svg | ImageClass = skin-invert-image | ImageSize = 250px | IUPACName = O1,O7-Di(5′-deoxyuridin-5′-yl) tetrahydrogen tetraphosphate | SystematicName = O1,O7-Bis{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen tetraphosphate | OtherNames = P1,P4-Bis(5'-uridyl) tetraphosphate; INS-365; Diquafosol tetrasodium |Section1= |Section2= |Section3= |Section5= | Section6 = }}

Diquafosol (tradename Diquas) is a pharmaceutical drug for the treatment of dry eye disease. It was approved for use in Japan in 2010. It is formulated as a 3% ophthalmic solution of the tetrasodium salt.

Excerpted from Wikipedia’s “diquafosol” article, available under the CC BY-SA 4.0 licence.

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