English

English Deutsch Español Français Italiano Nederlands Português Svenska 日本語

GeneQ18030325· pop 5· linked from 486 articles

P2RY6

Sign in to save

Also known as P2Y6, pyrimidinergic receptor P2Y6

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.

In the Vinony graph

Vinony's link graph records 486 inbound references to P2RY6, and connects out to adenosine receptor, PubMed and G protein-coupled recepteishon.

It sits within the topics Genes on human chromosome 11 and G protein-coupled receptors.

Vinony links it to 5 Wikipedia language editions.

Gene data

P2RY6

Name: pyrimidinergic receptor P2Y6
Type: protein-coding
Position: 73,264,498–73,305,103 (+)
Aliases: P2Y6
Ensembl: ENSG00000171631
RefSeq RNA: NM_001277204.2, NM_001277205.2, NM_001277206.2, NM_001277207.2, NM_001277208.2
RefSeq protein: NP_001264133.1, NP_001264134.1, NP_001264135.1, NP_001264136.1, NP_001264137.2

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013].

Gene Ontology

Biological process

phagocytosis G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of inositol trisphosphate biosynthetic process positive regulation of inositol trisphosphate biosynthetic process G protein-coupled purinergic nucleotide receptor signaling pathway

Molecular function

G protein-coupled ADP receptor activity G protein-coupled ADP receptor activity G protein-coupled receptor activity G protein-coupled receptor activity protein binding G protein-coupled purinergic nucleotide receptor activity G protein-coupled UDP receptor activity G protein-coupled UDP receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane membrane

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)GPCR downstream signalling G alpha (q) signalling events P2Y receptors Nucleotide-like (purinergic) receptors GPCR ligand binding GPCRs, Class A Rhodopsin-like

via MyGene.info

Gene · Ensembl

pyrimidinergic receptor P2Y6

Symbol: P2RY6
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:73,264,498-73,305,103
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 14289
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5031
genomic end: 73305103
genomic start: 73264498
chromosome: human chromosome 11
cytogenetic location: 11q13.4
expressed in: ascending aorta

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
See also
References
Further reading
External links

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.

== Function ==

Excerpted from Wikipedia’s “P2RY6” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 11 G protein-coupled receptors