P2RY12

Also known as ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc)

P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors. This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. The P2Y12 receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

Gene data

P2RY12

Name: purinergic receptor P2Y12
Type: protein-coding
Aliases: ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

purinergic receptor P2Y12

Symbol: P2RY12
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:151,336,843-151,384,765
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein P2RY12 PDB 1T78.png

Show 6 more facts

HomoloGene ID: 11260
exact match: identifiers.org/ncbigene/64805
genomic end: 151384753
genomic start: 151336843
Commons category: Purinergic P2Y12 receptors
cytogenetic location: 3q25.1

Sources (7)

via Wikidata · CC0

~3 min read

Article

5 sections

Contents

P2Y<sub>12</sub> antagonists
For acute coronary syndrome
Antiplatelet treatment of STEMI
References
External links

In the field of purinergic signaling, the P2Y12 protein on the periphery is found mainly but not exclusively on the surface of blood platelets, and is an important regulator in blood clotting. In the central nervous system, this receptor has been found expressed exclusively on microglia, where it is necessary for physiological and pathological microglial actions, such as monitoring neuronal functions and microglial neuroprotection.