PRSS2

Also known as TRY2, TRY8, TRYP2, protease, serine 2, serine protease 2

Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.

In the Vinony graph

Within Vinony's link graph, PRSS2 is referenced by 3 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It sits within the topics Genes on human chromosome 7 and Genes on human chromosome 9.

Its subject is documented across 5 Wikipedia language editions.

Gene data

PRSS2

Name: serine protease 2
Type: protein-coding
Position: 142,760,398–142,774,564 (+)
Aliases: TRY2, TRY8, TRYP2
Ensembl: ENSG00000275896
RefSeq RNA: NM_001303414.2, NM_002770.4, NR_130149.2, XM_054358659.1
RefSeq protein: NP_001290343.1, NP_002761.1, XP_054214634.1

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015].