PRSS8

Also known as CAP1, PROSTASIN, protease, serine 8, serine protease 8

Prostasin is a protein that in humans is encoded by the PRSS8 gene.

Gene data

PRSS8

Name: serine protease 8
Type: protein-coding
Aliases: CAP1, PROSTASIN

This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016].

via MyGene.info

Gene · Ensembl

serine protease 8

Symbol: PRSS8
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:31,131,433-31,135,727
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PRSS8 PDB 3DFJ.png

Show 5 more facts

HomoloGene ID: 20613
exact match: identifiers.org/ncbigene/5652
genomic end: 31135727
genomic start: 31142756
cytogenetic location: 16p11.2

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Prostasin is a protein that in humans is encoded by the PRSS8 gene.

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.