PTPRN

Also known as IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, protein tyrosine phosphatase, receptor type N, protein tyrosine phosphatase receptor type N

Receptor-type tyrosine-protein phosphatase-like N, also called "IA-2", is an enzyme that in humans is encoded by the PTPRN gene.

Gene data

PTPRN

Name: protein tyrosine phosphatase receptor type N
Type: protein-coding
Aliases: IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].

via MyGene.info

Gene · Ensembl

protein tyrosine phosphatase receptor type N

Symbol: PTPRN
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:219,289,623-219,309,648
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PTPRN PDB 2i1y.png

Show 5 more facts

HomoloGene ID: 48142
exact match: identifiers.org/ncbigene/5798
genomic end: 220174370
genomic start: 220154345
cytogenetic location: 2q35

Sources (3)

via Wikidata · CC0

~5 min read

Article

8 sections

Contents

Overview
Structure
Function
Autoantigen in Type 1 Diabetes
Autoantibodies in Type 1 Diabetes
Interactions
References
Further reading

Receptor-type tyrosine-protein phosphatase-like N, also called "IA-2", is an enzyme that in humans is encoded by the PTPRN gene.

== Overview == The IA-2 protein encoded by PTPRN gene is a member of the protein tyrosine phosphatase (PTP) family and PTPRN subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.