CDKN2B

Name

cyclin dependent kinase inhibitor 2B

Type

protein-coding

Position

22,002,900–22,009,325 (−)

Aliases

CDK4I, INK4B, MTS2, P15, TP15, p15INK4b

Ensembl

ENSG00000147883

RefSeq RNA

NM_004936.4, NM_078487.2

RefSeq protein

NP_004927.2, NP_511042.1

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].

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Gene · Ensembl

cyclin dependent kinase inhibitor 2B

Symbol

CDKN2B

Biotype

Protein coding

Organism

Homo sapiens

Location

9:22,002,900-22,009,325

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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