CDKN2B
Sign in to saveAlso known as CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.
Gene data
CDKN2B- Name
- cyclin dependent kinase inhibitor 2B
- Type
- protein-coding
- Aliases
- CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
cyclin dependent kinase inhibitor 2B
- Symbol
- CDKN2B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:22,002,900-22,009,325
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 55859
- exact match
- identifiers.org/ncbigene/1030
- genomic end
- 22009305
- genomic start
- 22002902
- cytogenetic location
- 9p21.3
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.
== Function ==