Polycomb complex protein BMI-1
Sign in to savePolycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.
Protein · UniProt
Polycomb complex protein BMI-1
- Gene
- BMI1
- Organism
- Homo sapiens (Human)
- Length
- 105 aa
- Molecular mass
- 12,248 Da
- Evidence
- 4: Predicted
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RN…
Swiss-Prot (reviewed) · via UniProt
~4 min read
Encyclopedic overview
8 sectionsContents
- Function
- Structure
- Clinical significance
- Interactions
- See also
- References
- External links
- Further reading
Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.
== Function ==
Excerpted from Wikipedia’s “Polycomb complex protein BMI-1” article, available under the CC BY-SA 4.0 licence.