FCRL3
Sign in to saveAlso known as CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.
Gene data
FCRL3- Name
- Fc receptor like 3
- Type
- protein-coding
- Position
- 157,674,321–157,700,901 (−)
- Aliases
- CD307c, FCRH3, IFGP3, IRTA3, MAIA, SPAP2
- Ensembl
- ENSG00000160856
- RefSeq RNA
- NM_001024667.1, NM_001320333.2, NM_052939.4, NR_135214.2, NR_135215.2
- RefSeq protein
- NP_001307262.1, NP_443171.2, XP_006711208.1, XP_054190135.1
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
Fc receptor like 3
- Symbol
- FCRL3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:157,674,321-157,700,901
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 76447
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/115352
- genomic end
- 157700769
- genomic start
- 157644111
- chromosome
- human chromosome 1
- cytogenetic location
- 1q23.1
via Wikidata · CC0
~6 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Signalling
- Expression
- Function
- Potential role in disease
- References
- Further reading
Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motif (ITAM) and immunoreceptor-tyrosine inhibitory motif (ITIM) in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
Excerpted from Wikipedia’s “FCRL3” article, available under the CC BY-SA 4.0 licence.