FHL3

Name

four and a half LIM domains 3

Type

protein-coding

Position

37,994,394–38,006,380 (−)

Aliases

SLIM2

Ensembl

ENSG00000183386

RefSeq RNA

NM_001243878.2, NM_004468.5

RefSeq protein

NP_001230807.1, NP_004459.2

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

via MyGene.info

Gene · Ensembl

four and a half LIM domains 3

Symbol

FHL3

Biotype

Protein coding

Organism

Homo sapiens

Location

1:37,994,394-38,006,380

Strand

Reverse (−)

Assembly

GRCh38

• The Roles of FHL3 in Cancer.Frontiers in oncology · 2022
• AMBP protects against aortic valve calcification by inhibiting ERK1/2 and JNK pathways mediated by FHL3.Theranostics · 2025
• FHL3 gene regulates bovine skeletal muscle cell growth through the PI3K/Akt/mTOR signaling pathway.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2024
• Clinical, immunological and genetic findings in patients with UNC13D deficiency (FHL3): A systematic review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021
• FHL3 promotes the formation of fast glycolytic muscle fibers by interacting with YY1 and muscle glycolytic metabolism.Cellular and molecular life sciences : CMLS · 2023

via PubMed

Wikidata facts

Image

Protein FHL3 PDB 1wyh.png

via Wikidata · CC0