FHL2
Sign in to saveAlso known as AAG11, DRAL, FHL-2, SLIM-3, SLIM3, four and a half LIM domains 2
Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.
Gene data
FHL2- Name
- four and a half LIM domains 2
- Type
- protein-coding
- Aliases
- AAG11, DRAL, FHL-2, SLIM-3, SLIM3
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016].
via MyGene.info
Gene · Ensembl
four and a half LIM domains 2
- Symbol
- FHL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:105,352,159-105,438,585
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein FHL2 PDB 1x4k.png
Show 5 more facts
- HomoloGene ID
- 20372
- exact match
- identifiers.org/ncbigene/2274
- genomic end
- 106054970
- genomic start
- 105974169
- cytogenetic location
- 2q12.2
Sources (3)
via Wikidata · CC0
~8 min read
Article
15 sectionsContents
- Function
- Family
- Gene
- Tissue distribution
- Regulation of expression
- Clinical significance
- Breast cancer
- Gastrointestinal cancer
- Liver cancer
- Prostate cancer
- Interactions
- Notes
- References
- Further reading
- External links
Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.
== Function ==