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GeneQ18027956· pop 5· linked from 75 articles

INSL3

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Also known as RLF, RLNL, ley-I-L, insulin like 3

Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene.

In the Vinony graph

Vinony's link graph records 75 inbound references to INSL3, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 19.

Vinony links it to 5 Wikipedia language editions.

Gene data

INSL3

Name: insulin like 3
Type: protein-coding
Position: 17,816,512–17,821,574 (−)
Aliases: RLF, RLNL, ley-I-L
Ensembl: ENSG00000248099
RefSeq RNA: NM_001265587.2, NM_005543.4
RefSeq protein: NP_001252516.1, NP_005534.2

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].

Gene Ontology

Biological process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cell-cell signaling spermatogenesis positive regulation of epithelial cell migration positive regulation of wound healing G protein-coupled serotonin receptor signaling pathway

Molecular function

G protein-coupled receptor binding protease binding signaling receptor binding insulin receptor binding hormone activity hormone activity protein binding

Cellular component

extracellular region extracellular region extracellular region

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Relaxin signaling pathway - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Peptide ligand-binding receptors GPCR downstream signalling G alpha (s) signalling events Relaxin receptors GPCR ligand binding

via MyGene.info

Gene · Ensembl

insulin like 3

Symbol: INSL3
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:17,816,512-17,821,574
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein INSL3 PDB 2h8b.png

Show 8 more facts

HomoloGene ID: 4048
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3640
genomic end: 17932383
genomic start: 17927321
chromosome: human chromosome 19
cytogenetic location: 19p13.11
genetic association: cryptorchidism

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene.

== Function ==

Excerpted from Wikipedia’s “INSL3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 19