PDGFB

Name

platelet derived growth factor subunit B

Type

protein-coding

Position

39,223,359–39,244,982 (−)

Aliases

IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis

Ensembl

ENSG00000100311

RefSeq RNA

NM_002608.4, NM_033016.3, XM_047441393.1, XM_047441394.1, XM_054325675.1

RefSeq protein

NP_002599.1, NP_148937.1, XP_047297349.1, XP_047297350.1, XP_054181650.1

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

via MyGene.info

Gene · Ensembl

platelet derived growth factor subunit B

Symbol

PDGFB

Biotype

Protein coding

Organism

Homo sapiens

Location

22:39,221,746-39,244,982

Strand

Reverse (−)

Assembly

GRCh38

• Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma.International journal of molecular sciences · 2023
• Bone-derived PDGF-BB drives brain vascular calcification in male mice.The Journal of clinical investigation · 2023
• KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway.International journal of biological sciences · 2024
• Intratumoral PDGFB gene predominantly expressed in endothelial cells is associated with angiogenesis and lymphangiogenesis, but not with metastasis in breast cancer.Breast cancer research and treatment · 2022
• Breaking the feed forward inflammatory cytokine loop in the tumor microenvironment of PDGFB-driven glioblastomas.The Journal of clinical investigation · 2023

via PubMed

Wikidata facts

Image

Protein PDGFB PDB 1pdg.png

via Wikidata · CC0