Structure via PubChem · Public domain (PubChem)
5,7,8-trihydroxyflavone
Sign in to saveAlso known as 2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one, Norwogonin
Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap). It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).
Chemical data
- Formula
- C15H10O5
- Molecular weight
- 270.24 g/mol
- IUPAC name
- 5,7,8-trihydroxy-2-phenylchromen-4-one
- SMILES
- C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O
- InChIKey
- ZFKKRRMUPBBYRS-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 87 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- flavone
- Mass
- 270.052823
Show 4 more facts
- found in taxon
- Scutellaria strigillosa
- canonical SMILES
- C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O
- chemical formula
- C₁₅H₁₀O₅
- Commons category
- Norwogonin
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap). It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).
== See also == Tropomyosin receptor kinase B § Agonists
Excerpted from Wikipedia’s “5,7,8-trihydroxyflavone” article, available under the CC BY-SA 4.0 licence.