TCL1A
Sign in to saveAlso known as TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A
T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.
In the Vinony graph
Within Vinony's link graph, TCL1A is referenced by 7 other articles, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Its subject is documented across 6 Wikipedia language editions.
Gene data
TCL1A- Name
- TCL1 family AKT coactivator A
- Type
- protein-coding
- Position
- 95,694,156–95,714,196 (−)
- Aliases
- TCL1
- Ensembl
- ENSG00000100721
- RefSeq RNA
- NM_001098725.2, NM_021966.3, NR_049726.2
- RefSeq protein
- NP_001092195.1, NP_068801.1
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TCL1 family AKT coactivator A
- Symbol
- TCL1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:95,694,156-95,714,196
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TCL1A PDB 1jsg.png
Show 8 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 7565
- exact match
- identifiers.org/ncbigene/8115
- genomic end
- 96180533
- genomic start
- 95709947
- chromosome
- human chromosome 14
- cytogenetic location
- 14q32.13
- expressed in
- bone marrow
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.
== Interactions ==
Excerpted from Wikipedia’s “TCL1A” article, available under the CC BY-SA 4.0 licence.