TAL1
Sign in to saveAlso known as SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
__NOTOC__ T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.
Gene data
TAL1- Name
- TAL bHLH transcription factor 1, erythroid differentiation factor
- Type
- protein-coding
- Aliases
- SCL, TCL5, bHLHa17, tal-1
Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
TAL bHLH transcription factor 1, erythroid differentiation factor
- Symbol
- TAL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:47,216,290-47,232,225
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
1,229 papers- Transcription Factor TAL1 in Erythropoiesis.Advances in experimental medicine and biology · 2024
- SCL/TAL1: a multifaceted regulator from blood development to disease.Blood · 2017
- SCL/TAL1 in Hematopoiesis and Cellular Reprogramming.Current topics in developmental biology · 2016
- TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia.Experimental hematology · 2017
- Towards methylation-based redefinition of TAL1 positive T-cell acute lymphoblastic leukaemia (T-ALL).Leukemia · 2025
via PubMed
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2400
- exact match
- identifiers.org/ncbigene/6886
- genomic end
- 47232225
- genomic start
- 47681962
- cytogenetic location
- 1p33
Sources (4)
via Wikidata · CC0
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4 sectionsContents
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__NOTOC__ T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.