TLX1
Sign in to saveAlso known as HOX11, TCL3, T-cell leukemia homeobox 1, T cell leukemia homeobox 1
T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.
Gene data
TLX1- Name
- T cell leukemia homeobox 1
- Type
- protein-coding
- Position
- 101,131,011–101,137,789 (+)
- Aliases
- HOX11, TCL3
- Ensembl
- ENSG00000107807
- RefSeq RNA
- NM_001195517.2, NM_005521.4, XM_011539744.4, XM_054365703.1
- RefSeq protein
- NP_001182446.1, NP_005512.1, XP_011538046.1, XP_054221678.1
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
T cell leukemia homeobox 1
- Symbol
- TLX1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:101,131,011-101,137,789
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 4031
- genomic end
- 101137789
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3195
- genomic start
- 101131300
- chromosome
- human chromosome 10
- cytogenetic location
- 10q24.31
- expressed in
- left ventricle
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.
== Interactions ==
Excerpted from Wikipedia’s “TLX1” article, available under the CC BY-SA 4.0 licence.