CD1e molecule
Sign in to saveAlso known as hCD1e, differentiation antigen CD1-alpha-3, T-cell surface glycoprotein CD1e, membrane-associated, CD1E, leukocyte differentiation antigen, CD1E antigen, e polypeptide, R2G1, thymocyte antigen CD1E
T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene.
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Within Vinony's link graph, CD1e molecule is referenced by 359 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It sits within the topics Clusters of differentiation and Genes on human chromosome 1.
Its subject is documented across 5 Wikipedia language editions.
Protein · UniProt
T-cell surface glycoprotein CD1e, membrane-associated
- Gene
- CD1E
- Organism
- Homo sapiens (Human)
- Length
- 388 aa
- Molecular mass
- 43,626 Da
- Evidence
- 1: Evidence at protein level
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 1 more fact
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene.
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Several alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined.
Excerpted from Wikipedia’s “CD1e molecule” article, available under the CC BY-SA 4.0 licence.