File:Bruce_Beutler.jpg · Wikimedia Commons · See Wikimedia Commons
OverviewAI-generated
Bruce Beutler is an American physician, geneticist, immunologist, and university teacher. Born in Chicago in 1957, he has worked in the fields of immunology and physiology. His academic background includes education at the University of California, San Diego, and the Pritzker School of Medicine. He has been employed by Scripps Research and The Rockefeller University.
Beutler is a member of the German Academy of Sciences Leopoldina, the National Academy of Sciences, and the American Academy of Arts and Sciences. He has received several honors, including the Balzan Prize, the Albany Medical Center Prize, the William B. Coley Award, and the Nobel Prize in Physiology or Medicine. His published works include titles such as "Immunology, phenotype first" and "Toll-like receptor family members and their ligands."
Synthesized by Vinony from 32 facts across 7 sources: Wikidata, Crossref, Open Library, MusicBrainz, Nobel Prize, Vinony collections, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Person · Open Library
- Works
- 5
Top works
- Immunology, phenotype first
- Toll-like receptor family members and their ligands
- Toll-like receptor family members and their ligands
- Immunology, Phenotype First
- Tumor Necrosis Factors
via Open Library + Wikidata
Music · MusicBrainz
- Type
- Person
- Gender
- Male
- Origin
- United States
- Active from
- 1949-09-23
Discography
via MusicBrainz · CC0
Recent publications · Crossref
5 total works indexed
- Full-length transcriptome assembly from RNA-Seq data without a reference genome
· 2011 · cited 19,415x
- Initial sequencing and analysis of the human genome
· 2001 · cited 18,623x
- Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data
· 2012 · cited 17,974x
- The value of the world's ecosystem services and natural capital
· 1997 · cited 16,340x
- Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
· 2002 · cited 16,052x
via Crossref · CC0
Nobel Prize
- The Nobel Prize in Physiology or Medicine2011
“for their discoveries concerning the activation of innate immunity”
Shared · 1/4 portion
~27 min read
Encyclopedic overview
Bruce Alan Beutler (/ˈbɔɪtlər/ BOYT-lər; born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the activation of innate immunity." Beutler discovered the long-elusive receptor for lipopolysaccharide (LPS; also known as endotoxin). He did so by identifying spontaneous mutations in the gene coding for mouse Toll-like receptor 4 (Tlr4) in two unrelated strains of LPS-refractory mice and proving they were responsible for that phenotype. Subsequently, and chiefly through the work of Shizuo Akira, other TLRs were shown to detect signature molecules of most infectious microbes, in each case triggering an innate immune response.
The other half of the Nobel Prize went to Ralph M. Steinman for "his discovery of the dendritic cell and its role in adaptive immunity."
Excerpted from Wikipedia’s “Bruce Beutler” article, available under the CC BY-SA 4.0 licence.