Also known as DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2, uracil DNA glycosylase
protein-coding gene in the species Homo sapiens
Gene data
UNG- Name
- uracil DNA glycosylase
- Type
- protein-coding
- Position
- 109,097,572–109,126,725 (+)
- Aliases
- DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2
- Ensembl
- ENSG00000076248
- RefSeq RNA
- NM_003362.4, NM_080911.3
- RefSeq protein
- NP_003353.1, NP_550433.1
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
uracil DNA glycosylase
- Symbol
- UNG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:109,097,569-109,126,725
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein UNG PDB 1akz.png
Show 5 more facts
- HomoloGene ID
- 6585
- exact match
- identifiers.org/ncbigene/7374
- genomic end
- 109548797
- genomic start
- 109097597
- cytogenetic location
- 12q24.11
via Wikidata · CC0