UMPS

Name

uridine monophosphate synthetase

Type

protein-coding

Position

124,730,433–124,749,273 (+)

Aliases

ODC, OPRT

Ensembl

ENSG00000114491

RefSeq RNA

NM_000373.4, NR_033434.2, NR_033437.2, XR_001740253.3, XR_008486790.1

RefSeq protein

NP_000364.1

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].

via MyGene.info

Gene · Ensembl

uridine monophosphate synthetase

Symbol

UMPS

Biotype

Protein coding

Organism

Homo sapiens

Location

3:124,730,433-124,749,384

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein UMPS PDB 2eaw.png

via Wikidata · CC0