Gene data
UMPS- Name
- uridine monophosphate synthetase
- Type
- protein-coding
- Position
- 124,730,433–124,749,384 (+)
- Aliases
- ODC, OPRT
- Ensembl
- ENSG00000114491
- RefSeq RNA
- NM_000373.4, NR_033434.2, NR_033437.2, XR_001740253.3, XR_008486790.1
- RefSeq protein
- NP_000364.1
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
uridine monophosphate synthetase
- Symbol
- UMPS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:124,730,433-124,749,384
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein UMPS PDB 2eaw.png
Show 8 more facts
- HomoloGene ID
- 319
- genomic end
- 124464040
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7372
- genomic start
- 124730433
- chromosome
- human chromosome 3
- cytogenetic location
- 3q21.2
- genetic association
- orotic aciduria
Sources (6)
via Wikidata · CC0