vitamin D receptor
Sign in to saveAlso known as vitamin D nuclear receptor variant 1, protein phosphatase 1, regulatory subunit 163, 1,25-dihydroxyvitamin D3 receptor, vitamin D (1,25- dihydroxyvitamin D3) receptor, VDR, Calcitriol Receptor, vitamin D3 receptor, Calcitriol Receptors
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, vitamin D receptor is referenced by 900 other articles, and connects out to vitamin D, PubMed and cholecalciferol.
It sits within the topics Genes on human chromosome 12, Intracellular receptors and Transcription factors.
Its subject is documented across 14 Wikipedia language editions.
Protein · UniProt
Vitamin D3 receptor
- Gene
- VDR
- Organism
- Homo sapiens (Human)
- Length
- 427 aa
- Molecular mass
- 48,289 Da
- Evidence
- 1: Evidence at protein level
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid …
Swiss-Prot (reviewed) · via UniProt
Research
14,007 papers- Vitamin D receptor gene polymorphisms in atopy.Immunity, inflammation and disease · 2021
- Vitamin D and its receptor polymorphisms are associated with glaucoma.Journal francais d'ophtalmologie · 2020
- Vitamin D Receptor Influences Intestinal Barriers in Health and Disease.Cells · 2022
- Vitamin D receptor polymorphisms and the susceptibility of Parkinson's disease.Neuroscience letters · 2019
- An Update on Vitamin D Metabolism.International journal of molecular sciences · 2020
via PubMed
Clinical Trials
75 registered- PHASE2UNKNOWNEvaluation of the High Dose Vitamin D3 Supplementation Effect and Influence of Polymorphism VDR Gene on Oxidative Stress and Inflammatory Process in ElderlyFederal University of Paraíba · NCT02222649
- TERMINATEDUltraviolet Light Exposure and Immunosuppression in Cutaneous MelanomaNew Mexico Cancer Research Alliance · NCT00996827
- NACOMPLETEDThe VALIDATE-D StudyBrigham and Women's Hospital · NCT01635062
- NACOMPLETEDEffects of Vitamin D Supplementation on Obesity, Inflammatory and Metabolic MarkersTirang R. Neyestani, Ph.D. · NCT05376865
- PHASE1COMPLETEDEfficiency of Vitamin D3 and 25-hydroxyvitamin D3 on Transcriptomic Changes of Low Vitamin D RespondersUniversity of Eastern Finland · NCT03537027
- NAENROLLING_BY_INVITATIONThe Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic ConjunctivitisChina Medical University Hospital · NCT05839938
Wikidata facts
- Instance of
- protein
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P11473
- physically interacts with
- tacalcitol
via Wikidata · CC0