Structure via PubChem · Public domain (PubChem)
bemegride
Sign in to saveBemegride, sold under the brand name Megimide among others, is a central nervous system (CNS) stimulant first manufactured in 1911, and which has been used in hypnotic overdose.
Chemical data
- Formula
- C8H13NO2
- Molecular weight
- 155.19 g/mol
- IUPAC name
- 4-ethyl-4-methylpiperidine-2,6-dione
- SMILES
- CCC1(CC(=O)NC(=O)C1)C
- InChIKey
- ORRZGUBHBVWWOP-UHFFFAOYSA-N
- XLogP
- 0.7
- Polar surface area
- 46.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- respiratory system disease
via ChEMBL · EBI
Research
556 papers- Bemegride analepsis.British medical journal · 1958
- [Bemegride].Ceskoslovenska farmacie · 1965
- Phenobarbitone poisoning treated with bemegride.Lancet (London, England) · 1956
- Thiopentone anaesthesia terminated by bemegride.Anaesthesia · 1958
- Bemegride in the treatment of acute sedative intoxication.Canadian Medical Association journal · 1960
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 155.095
Show 4 more facts
- subject has role
- stimulant
- chemical formula
- C₈H₁₃NO₂
- canonical SMILES
- CCC1(CC(=O)NC(=O)C1)C
- Commons category
- Bemegride
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Synthesis
- Society and culture
- John Bodkin Adams case
- References
Bemegride, sold under the brand name Megimide among others, is a central nervous system (CNS) stimulant first manufactured in 1911, and which has been used in hypnotic overdose.
As with other chemoreceptor agonists, it is a potent emetic at doses above those normally used in management of barbiturate overdose, although vomiting and aspiration are a concern during treatment. It is a controlled substance in some countries, and is sometimes used to induce convulsions in experimental animals.
Excerpted from Wikipedia’s “bemegride” article, available under the CC BY-SA 4.0 licence.