Structure via PubChem · Public domain (PubChem)
tiapride
Sign in to saveTiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain. It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly. A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride and amisulpride known for their dopamine antagonist effects.
Chemical data
- Formula
- C15H24N2O4S
- Molecular weight
- 328.4 g/mol
- IUPAC name
- N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide
- SMILES
- CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC
- InChIKey
- JTVPZMFULRWINT-UHFFFAOYSA-N
- XLogP
- 0.9
- Polar surface area
- 84.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- anxiety, Dementia, Tourette syndrome, psychosis
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 328.146
Show 4 more facts
- Commons category
- Tiapride
- chemical formula
- C₁₅H₂₄N₂O₄S
- canonical SMILES
- CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC
- isomeric SMILES
- CCN(CC)CC/N=C(/C1=CC(=CC=C1OC)S(=O)(=O)C)\O
via Wikidata · CC0
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Alcoholism
- Agitation and aggression
- Movement disorders
- Side effects
- Pharmacodynamics
- Pharmacokinetics
- Availability
- See also
- References
Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain. It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly. A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride and amisulpride known for their dopamine antagonist effects.
==Medical uses==
Excerpted from Wikipedia’s “tiapride” article, available under the CC BY-SA 4.0 licence.