Structure via PubChem · Public domain (PubChem)
piperacetazine
Sign in to savePiperacetazine (Quide) is an antipsychotic prodrug, most notably used for schizophrenia. It is a phenothiazine derivative. Based on clinical trial data, it appears to have similar efficacy as chlorpromazine. However, very little research has been done since the 1970s, and it is not a commonly used drug today.
Chemical data
- Formula
- C24H30N2O2S
- Molecular weight
- 410.6 g/mol
- IUPAC name
- 1-[10-[3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl]phenothiazin-2-yl]ethanone
- SMILES
- CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCC(CC4)CCO
- InChIKey
- BTFMCMVEUCGQDX-UHFFFAOYSA-N
- XLogP
- 4
- Polar surface area
- 69.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1969
- Admin. routes
- oral
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 410.203
Show 4 more facts
- Commons category
- Piperacetazine
- canonical SMILES
- CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCC(CC4)CCO
- chemical formula
- C₂₄H₃₀N₂O₂S
- subject has role
- alpha blocker
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Side effects
- References
Piperacetazine (Quide) is an antipsychotic prodrug, most notably used for schizophrenia. It is a phenothiazine derivative. Based on clinical trial data, it appears to have similar efficacy as chlorpromazine. However, very little research has been done since the 1970s, and it is not a commonly used drug today.
== Side effects == The side effect profile of piperacetazine is similar to that of other typical antipsychotics. The most common side effects of piperacetazine are dizziness, drowsiness, fainting, orthostatic hypotension, and extrapyramidal symptoms. Less common side effects include nausea, vomiting, bradycardia, euphoria, and headache. Rare side effects include leukopenia, thrombocytopenia, galactorrhea, amenorrhea, seizures, urinary retention, and jaundice.
Excerpted from Wikipedia’s “piperacetazine” article, available under the CC BY-SA 4.0 licence.