benperidol

Also known as MCN-JR-4584, R-4584

Benperidol, sold under the trade name Anquil among others, is a typical antipsychotic primarily used to treat hypersexuality syndromes and can be used to treat schizophrenia. It is a highly potent butyrophenone derivative and is the most potent neuroleptic in the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% the potency per dose of haloperidol). It is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 459533587
Drug.IUPAC_name: 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
Drug.image: Benperidol.svg
Drug.image_class: skin-invert-image
Drug.alt: Skeletal formula of benperidol
Drug.width: 250px
Drug.image2: Benperidol 3D ball.png
Drug.image_class2: bg-transparent
Drug.alt2: Ball-and-stick model of the benperidol molecule
Drug.width2: 250px
Drug.tradename: Anquil, Frenactil
Drug.legal_AU: S4 (Prescription only)
Drug.legal_US: Rx-only
Drug.routes_of_administration: Oral
Drug.elimination_half life: 8 hours
Drug.CAS_number: 2062-84-2
Drug.ATC_prefix: N05

via Wikipedia infobox

Research

835 papers

Benperidol for schizophrenia.The Cochrane database of systematic reviews · 2005
Benperidol for schizophrenia.The Cochrane database of systematic reviews · 2002
Benperidol in the treatment of sexual offenders.Medicine, science, and the law · 1973
Droperidol.British journal of anaesthesia · 1971
Influence of intravenous administration of the antipsychotic drug benperidol on the QT interval.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2017

via PubMed

Wikidata facts

Mass: 381.185255

Show 4 more facts

chemical formula: C₂₂H₂₄FN₃O₂
canonical SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
Commons category: Benperidol
defined daily dose: 1.5

Sources (3)

via Wikidata · CC0

~5 min read

Article

6 sections

Contents

Pharmacology
Pharmacodynamics
Pharmacokinetics
Synthesis
See also
References

{{Infobox drug | Verifiedfields = changed | verifiedrevid = 459533587 | IUPAC_name = 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one | image = Benperidol.svg | image_class = skin-invert-image | alt = Skeletal formula of benperidol | width = 250px | image2 = Benperidol 3D ball.png | image_class2 = bg-transparent | alt2 = Ball-and-stick model of the benperidol molecule | width2 = 250px