nalmefene

Also known as JF-1, nalmetrene, ORF-11676, Revex® (nalmefene hydrochloride), Selincro®

Nalmefene, sold under the brand name Revex among others, is a medication that is used in the treatment of opioid overdose and alcohol dependence. Nalmefene belongs to the class of opioid antagonists and can be taken by mouth, administered by injection, or delivered through nasal administration.

Key facts

Drug.Verifiedfields: verified
Drug.Watchedfields: verified
Drug.verifiedrevid: 462258343
Drug.image: Nalmefene.svg
Drug.image_class: skin-invert-image
Drug.width: 150
Drug.tradename: Revex, others
Drug.MedlinePlus: a605043
Drug.DailyMedID: Nalmefene
Drug.routes_of_administration: By mouth, intranasal, intramuscular, intravenous, subcutaneous
Drug.class: Opioid antagonist
Drug.ATC_prefix: N07
Drug.ATC_suffix

Article

17 sections

Contents

Medical uses
Opioid overdose
Alcohol dependence
Side effects
Very common
Common
Pharmacology
Pharmacodynamics
Opioid receptor blockade
Metabolism
Chemistry
Society and culture
Legal status
United States
European Union
Research
References

In terms of its chemical structure and biological activity, nalmefene is similar to another opioid antagonist called naltrexone, as they are both derivatives of opiates. However, nalmefene offers certain advantages over naltrexone. These include a longer elimination half-life, which means it stays in the body for a longer duration, improved absorption when taken by mouth, and no observed liver toxicity that is dependent on the dosage.