ethylmorphine

Also known as Dionine, Ethyl morphine, SID144206163, SID50113064, codethyline

Ethylmorphine (also known as codethyline, dionine, and ethyl morphine) is an opioid analgesic and antitussive.

Chemical data

Formula: C19H23NO3
Molecular weight: 313.4 g/mol
IUPAC name: (4R,4aR,7S,7aR,12bS)-9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
SMILES: CCOC1=C2C3=C(C[C@@H]4[C@H]5[C@]3(CCN4C)[C@@H](O2)[C@H](C=C5)O)C=C1
InChIKey: OGDVEMNWJVYAJL-LEPYJNQMSA-N
XLogP: 1.5
Polar surface area: 41.9 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

965 papers

Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose.British journal of clinical pharmacology · 1995
[Assessment of the intake of opiates (heroin, morphine, codeine and ethylmorphine) by the analysis of intermediate metabolites in the urine: which are the criteria to adopt?].Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis · 1991
Core in Cup Ethylmorphine Hydrochloride Tablet for Dual Fast and Sustained Pain Relief: Formulation, Characterization, and Pharmacokinetic Study.AAPS PharmSciTech · 2020
Ethylmorphine metabolism in isolated rat hepatocytes.Pharmacology & toxicology · 1993
Ethylmorphine concentrations in human samples in an overdose case.Archives of toxicology · 1994

via PubMed

Wikidata facts

Mass: 313.168

Show 5 more facts

Commons category: Ethylmorphine
chemical formula: C₁₉H₂₃NO₃
isomeric SMILES: CCOC1=C2C3=C(C[C@@H]4[C@H]5[C@]3(CCN4C)[C@@H](O2)[C@H](C=C5)O)C=C1
canonical SMILES: CCOC1=C2C3=C(CC4C5C3(CCN4C)C(O2)C(C=C5)O)C=C1
defined daily dose: 50

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Side effects
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References

Ethylmorphine (also known as codethyline, dionine, and ethyl morphine) is an opioid analgesic and antitussive.

==Side effects== Adverse effects are similar to other opioids and include drowsiness, constipation, vertigo, nausea, vomiting, and respiratory depression. Contraindications include asthma, respiratory insufficiency, and age under 8. Ethylmorphine may affect the user's ability to drive and operate heavy machinery, and may cause chemical dependence or addiction at high doses.