Structure via PubChem · Public domain (PubChem)
tyloxapol
Sign in to saveAlso known as Superinone
Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen.
Chemical data
- Formula
- C51H80O6
- Molecular weight
- 789.2 g/mol
- IUPAC name
- 2-[2-[[2-(2-hydroxyethoxy)-3-[[2-(2-hydroxyethoxy)-3-methyl-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol
- SMILES
- CC1=CC(=CC(=C1OCCO)CC2=CC(=CC(=C2OCCO)CC3=C(C=CC(=C3)C(C)(C)CC(C)(C)C)OCCO)C(C)(C)CC(C)(C)C)C(C)(C)CC(C)(C)C
- InChIKey
- UTFVNNPSMPINLE-UHFFFAOYSA-N
- XLogP
- 14.2
- Polar surface area
- 88.4 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Unknown
- First approval
- 1990
- Admin. routes
- parenteral
via ChEMBL · EBI
Research
757 papers- The effect of Tyloxapol on the metabolome of Mycobacterium tuberculosis.Journal of microbiological methods · 2024
- Tyloxapol inhibits RANKL-stimulated osteoclastogenesis and ovariectomized-induced bone loss by restraining NF-κB and MAPK activation.Journal of orthopaedic translation · 2021
- Lipopolysaccharide and tyloxapol accelerate the development of atherosclerosis in mice.Lipids · 2022
- Pterostilbene alleviated NAFLD via AMPK/mTOR signaling pathways and autophagy by promoting Nrf2.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2023
- Tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum.Journal of bacteriology · 2026
via PubMed
Wikidata facts
Show 4 more facts
- chemical formula
- C₁₇H₂₈O₃
- defined daily dose
- 5
- subject has role
- surfactant
- canonical SMILES
- Cc1cc(C(C)(C)CC(C)(C)C)cc(Cc2cc(C(C)(C)CC(C)(C)C)cc(Cc3cc(C(C)(C)CC(C)(C)C)ccc3OCCO)c2OCCO)c1OCCO
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen.
With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals.
Excerpted from Wikipedia’s “tyloxapol” article, available under the CC BY-SA 4.0 licence.
Available in 7 languages
via Wikidata sitelinks · CC0