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Structure via PubChem · Public domain (PubChem)
dimemorfan
Sign in to saveAlso known as dimemorphan
Dimemorfan (INN; JAN dimemorfan phosphate; also known as dimemorphan and 3,17-dimethylmorphinan; brand names Astomin, Dastosirr, and Tusben) is an antitussive (cough suppressant) of the morphinan family that is widely used in Japan and is also marketed in Spain and Italy. It was developed by Yamanouchi Pharmaceutical (now Astellas Pharma) and introduced in Japan in 1975. It was later introduced in Spain in 1981 and Japan in 1985.
Chemical data
- Formula
- C18H25N
- Molecular weight
- 255.4 g/mol
- IUPAC name
- (1S,9S,10S)-4,17-dimethyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
- SMILES
- CC1=CC2=C(C[C@H]3[C@@H]4[C@]2(CCCC4)CCN3C)C=C1
- InChIKey
- KBEZZLAAKIIPFK-NJAFHUGGSA-N
- XLogP
- 3.8
- Polar surface area
- 3.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Cough
via ChEMBL · EBI
Wikidata facts
- Mass
- 255.199
Show 4 more facts
- chemical formula
- C₁₈H₂₅N
- isomeric SMILES
- CC1=CC2=C(C[C@H]3[C@@H]4[C@]2(CCCC4)CCN3C)C=C1
- canonical SMILES
- CC1=CC2=C(CC3C4C2(CCCC4)CCN3C)C=C1
- subject has role
- antitussive
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Side effects
- Pharmacology
- See also
- References
Dimemorfan (INN; JAN dimemorfan phosphate; also known as dimemorphan and 3,17-dimethylmorphinan; brand names Astomin, Dastosirr, and Tusben) is an antitussive (cough suppressant) of the morphinan family that is widely used in Japan and is also marketed in Spain and Italy. It was developed by Yamanouchi Pharmaceutical (now Astellas Pharma) and introduced in Japan in 1975. It was later introduced in Spain in 1981 and Japan in 1985.
==Side effects== Adverse effects include nausea, somnolence, dry mouth, and decreased appetite.
Excerpted from Wikipedia’s “dimemorfan” article, available under the CC BY-SA 4.0 licence.