English
Structure via PubChem · Public domain (PubChem)
dimemorfan
Sign in to saveAlso known as dimemorphan
Dimemorfan (INN; JAN dimemorfan phosphate; also known as dimemorphan and 3,17-dimethylmorphinan; brand names Astomin, Dastosirr, and Tusben) is an antitussive (cough suppressant) of the morphinan family that is widely used in Japan and is also marketed in Spain and Italy. It was developed by Yamanouchi Pharmaceutical (now Astellas Pharma) and introduced in Japan in 1975. It was later introduced in Spain in 1981 and Japan in 1985.
In the Vinony graph
Vinony's link graph records 255 inbound references to dimemorfan, and connects out to antitussive, Astellas Pharma and Japan.
It sits within the topics Antitussives, Astellas Pharma and Drugboxes which contain changes to verified fields.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C18H25N
- Molecular weight
- 255.4 g/mol
- IUPAC name
- (1S,9S,10S)-4,17-dimethyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
- SMILES
- CC1=CC2=C(C[C@H]3[C@@H]4[C@]2(CCCC4)CCN3C)C=C1
- InChIKey
- KBEZZLAAKIIPFK-NJAFHUGGSA-N
- XLogP
- 3.8
- Polar surface area
- 3.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Cough
via ChEMBL · EBI
Wikidata facts
- Mass
- 255.199
Show 4 more facts
- chemical formula
- C₁₈H₂₅N
- isomeric SMILES
- CC1=CC2=C(C[C@H]3[C@@H]4[C@]2(CCCC4)CCN3C)C=C1
- canonical SMILES
- CC1=CC2=C(CC3C4C2(CCCC4)CCN3C)C=C1
- subject has role
- antitussive
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Side effects
- Pharmacology
- See also
- References
Dimemorfan (INN; JAN dimemorfan phosphate; also known as dimemorphan and 3,17-dimethylmorphinan; brand names Astomin, Dastosirr, and Tusben) is an antitussive (cough suppressant) of the morphinan family that is widely used in Japan and is also marketed in Spain and Italy. It was developed by Yamanouchi Pharmaceutical (now Astellas Pharma) and introduced in Japan in 1975. It was later introduced in Spain in 1981 and Japan in 1985.
==Side effects== Adverse effects include nausea, somnolence, dry mouth, and decreased appetite.
Excerpted from Wikipedia’s “dimemorfan” article, available under the CC BY-SA 4.0 licence.